被隔离的动物可能是恐惧和焦虑的模型吗?

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI:10.1016/0364-7722(81)90065-5

Silvio Garattini, Luigi Valzelli

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引用次数: 18

摘要

1.1. 分离的动物发展出复杂的症状病理学，可以在行为和神经化学上进行表征。主要的行为特征包括:强迫性攻击、学习障碍、探索障碍和性行为障碍，而主要的神经化学特征包括脑色氨酸含量减少、脑血清素周转量减少和脑多巴胺周转量增加。4.4.分离的攻击性小鼠对几种精神药物、三环抗抑郁药、β受体阻滞剂和苯二氮卓类药物的敏感性不同于分组的小鼠。所获得的结果将在利用这些动物模型研究对焦虑和恐惧症有活性的药物的可能性的框架内进行讨论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Is the isolated animal a possible model for phobia and anxiety?

1.
1. Isolated animals develop a complex symptopathology which can be characterized both behaviorally and neurochemically.
2.
2. The main behavioral features include: compulsive aggression, impairment of learning, exploration and sexual behavior, while the main neurochemical features include a decrease of brain tryptophan content and of brain serotonin turnover and an increased brain dopamine turnover.
3.
3. Isolated aggressive mice are differently sensitive than grouped animals and respond differently to several psychotropic drugs, tricyclic antidepressants, betablockers and benzodiazepines.
4.
4. The results obtained will be discussed in the frame of the possibility of utilizing these animals models to study drugs active on anxiety and phobia.

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