阿米替林对大鼠血清谷氨酸和游离色氨酸的影响。

Archiv Fur Psychiatrie Und Nervenkrankheiten Pub Date : 1982-01-01 DOI:10.1007/BF00345595

J S Kim, W Schmid-Burgk, D Claus, H H Kornhuber

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引用次数: 11

摘要

在大鼠中，慢性阿米替林(14天，10 mg/kg, IP)导致血清谷氨酸浓度显著升高，同时血清游离色氨酸升高。相比之下，阿米替林对血清总色氨酸和脑脊液谷氨酸水平没有影响。数据证实，抗抑郁药物可诱导抑郁症患者血清谷氨酸浓度升高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Effects of amitriptyline on serum glutamate and free tryptophan in rats.

In rats, chronic amitriptyline (14 days, 10 mg/kg, IP) administration resulted in a significant increase in the serum glutamate concentration and concomitant increase in the serum free tryptophan. In contrast, amitriptyline had no effect on the total serum tryptophan or CSF glutamate level. The data confirmed that antidepressant drugs may induce an increase of the serum glutamate concentration in depressive patients.

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Archiv Fur Psychiatrie Und Nervenkrankheiten

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