慢性髓性白血病的急性转化:自体移植后费城染色体消失。

J Reiffers, B David, P Bernard, G Vezon, G Marit, J Moulinier, A Broustet
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引用次数: 0

摘要

2例慢性粒细胞白血病(C.G.L.)患者行转化治疗,采用大剂量化疗和全身照射,并在诊断时收集并冷冻保存的造血干细胞进行自体移植。造血功能恢复的特点是费城染色体在大多数中期消失。本文讨论了一种治疗慢性肾衰竭的新方法。
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[Acute transformation of chronic myeloid leukemia: disappearance of the Philadelphia chromosome after autograft].

Two patients with chronic granulocytic leukemia (C.G.L.) undergoing transformation were treated by high dose chemotherapy and total body irradiation followed by autografting of hematopoietic stem cells collected and cryo-preserved at the time of diagnosis. Recovery of hematopoiesis was characterized by disappearance of the Philadelphia chromosome in most metaphases. A new approach of the management of C.G.L. is discussed.

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