多胺对超氧阴离子还原细胞色素C的抑制作用。

Biochemistry and experimental biology Pub Date : 1980-01-01

A Vanella, A Rapisarda, R Pinturo, V Rizza

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引用次数: 0

摘要

研究了多胺与酶促自由基的相互作用。采用黄嘌呤氧化酶-次黄嘌呤体系体外生成超氧阴离子(O-2)。结果表明，不同浓度(20 ~ 200 mM)的精胺或精胺均能抑制细胞色素c的还原;添加200 mM亚精胺或精胺时，抑制效果最好。腐胺(200mm)对细胞色素c的还原影响很小。

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Inhibitor effect of polyamines on reduction of cytochrome C by superoxide anion.

The interaction of polyamines with enzymatically generated free radicals was investigated. The superoxide anion (O-2) was generated in vitro using the xanthine oxidase-hypoxanthine system. Our results show that spermidine or spermine at different concentrations (20-200 mM) inhibit the reduction of cytochrome c; the highest levels of inhibition were obtained adding 200 mM spermidine or spermine. Putrescine (200 mM) affected the reduction of cytochrome c very little.

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Biochemistry and experimental biology

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