嘌呤能抑制大鼠门静脉肾上腺素能神经传递的进一步证据。

Acta physiologica latino americana Pub Date : 1981-01-01
M A Enero
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摘要

研究了腺苷对3h -去甲肾上腺素(3H-NA)释放的抑制作用,以及嘌呤受体对门静脉内递质释放的调控作用。不同浓度腺苷(10、30、100和300 μ m)的抑制作用随刺激频率的增加而降低,但不存在明显的浓度依赖性。四乙基铵(TEA)增强了跨壁刺激引起的3H-NA溢出。腺苷诱导的3H-NA溢出抑制被TEA拮抗。经壁刺激诱导的氚从预先标记为3H-NA或3h -腺嘌呤的组织中释放具有相似的分布模式。相比之下,(-)NA刺激大鼠门静脉时,嘌呤衍生物的溢出延迟,最大释放时间比跨壁刺激诱导的最大释放时间晚5 min。苯氧苄胺(Phenoxybenzamine, PBA)使3H-NA溢出增加2倍,但对跨壁刺激诱导的3h -嘌呤释放无影响。PBA减少了外源(-)NA对3h -嘌呤的释放。这些结果表明,在大鼠门静脉中,嘌呤化合物具有交界前和交界后的来源,而调节肾上腺素能神经传递的嘌呤可能是神经元来源的,可能独立于肾上腺素能神经支配。
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Further evidence for the purinergic inhibition of adrenergic neurotransmission in the rat portal vein.

The inhibition of 3H-noradrenaline (3H-NA) release by adenosine, and the possible involvement of purine receptors in the regulation of transmitter release in the portal vein were studied. The inhibitory effect of different concentrations of adenosine (10, 30, 100 and 300 microM) decreased with frequency of stimulation, but there was no marked concentration-dependence. Tetraethylammonium (TEA) enhanced the 3H-NA overflow induced by transmural stimulation. The adenosine-induced inhibition of 3H-NA overflow was antagonized by TEA. Transmural stimulation induced release of tritium from tissues prelabelled with either 3H-NA or 3H-adenine had a similar pattern of distribution. In contrast, when the rat portal vein was stimulated with (-) NA, the overflow of purine derivates was delayed and the maximum release was achieved 5 min later than the maximum induced by transmural stimulation. Phenoxybenzamine (PBA) increased 3H-NA overflow two-fold, but had no effect on the 3H-purine release induced by transmural stimulation. PBA reduced the 3H-purine release by exogenous (-) NA. These results indicate that in rat portal vein, the purine compounds have pre- and postjunctional origins and that the purine that modulates adrenergic neurotransmission might be of neuronal origin, possibly independent of adrenergic innervation.

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