肝病中的脂蛋白代谢。

P H Green
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引用次数: 0

摘要

肝病与血浆脂质和脂蛋白结构及代谢异常有关。这些异常并不是肝病类型所特有的。然而,这些变化的严重程度确实与肝脏疾病的严重程度相当。脂蛋白异常也可能具有预后意义;但血浆脂蛋白异常与更标准的肝功能检查之间没有很好的相关性。由于脂蛋白发生明显的紊乱,肝病为研究脂蛋白代谢提供了一个有用的模型。
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Lipoprotein metabolism in liver disease.

Liver disease is associated with abnormalities in plasma lipids and lipoprotein structure and metabolism. These abnormalities are not specific for the type of liver disease. The severity of the changes does, however, parallel the severity of the liver disease. Lipoprotein abnormalities may also have prognostic significance; but there is no good correlation between the abnormalities in plasma lipoproteins and more standard liver-function tests. Due to the marked derangements that occur in lipoproteins, liver disease provides a useful model to study lipoprotein metabolism.

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Tracers in metabolic research: radioisotope and stable isotope/mass spectrometry methods. Laboratory considerations: determination of cholesterol, triglyceride, phospholipid, and other lipids in blood and tissues. Fractionation of plasma lipoproteins: evaluation of preparative methods. Clinical and experimental methods for the determination of cholesterol absorption. The absorption of lipid and lipoprotein synthesis.
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