{"title":"[阿霉素对人体外溶血的血清增强作用]。","authors":"J Y Follézou, M Bizon, J Gicquel","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Human red cells lysis produced by adriamycin in vitro was investigated both in phosphate medium pH7 and in human serum. Drug induced hemolysis, that appeared with concentrations markedly above plasmatic levels seen in therapeutic, was stongly enhanced by serum. It is the first relations of modulation through a human serum factor of a biological action of adriamycin.</p>","PeriodicalId":10622,"journal":{"name":"Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie","volume":"296 1","pages":"25-8"},"PeriodicalIF":0.0000,"publicationDate":"1983-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Serum potentiation of hemolysis induced in vitro by adriamycin in man].\",\"authors\":\"J Y Follézou, M Bizon, J Gicquel\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Human red cells lysis produced by adriamycin in vitro was investigated both in phosphate medium pH7 and in human serum. Drug induced hemolysis, that appeared with concentrations markedly above plasmatic levels seen in therapeutic, was stongly enhanced by serum. It is the first relations of modulation through a human serum factor of a biological action of adriamycin.</p>\",\"PeriodicalId\":10622,\"journal\":{\"name\":\"Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie\",\"volume\":\"296 1\",\"pages\":\"25-8\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1983-01-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[Serum potentiation of hemolysis induced in vitro by adriamycin in man].
Human red cells lysis produced by adriamycin in vitro was investigated both in phosphate medium pH7 and in human serum. Drug induced hemolysis, that appeared with concentrations markedly above plasmatic levels seen in therapeutic, was stongly enhanced by serum. It is the first relations of modulation through a human serum factor of a biological action of adriamycin.
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