K Wierzba, B Wańkowicz, J Prokopczyk, A Piekarczyk
{"title":"呋喃妥因在怀孕大鼠体内的药代动力学。","authors":"K Wierzba, B Wańkowicz, J Prokopczyk, A Piekarczyk","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The investigation of nitrofurantoin (NTF) pharmacokinetics in pregnant rats was undertaken to estimate its cumulation in the fetus unit. It was found that pharmacokinetics of NTF is dose-dependent in non-pregnant rats. The biological half-life time increased from 0.24 to 0.41 and 0.72 h for NTF doses 10.20 and 40 mg/kg, respectively. The elimination of NTF was diminished in pregnant rats. The pharmacokinetic analysis revealed a possibility of strong NTF accumulation in the pregnant rats (increased K12/K21 ratio). Taking into account increased renal function in pregnancy, one may suspect that decreased elimination of NTF was rather caused by its significant cumulation in the changed tissue compartment.</p>","PeriodicalId":76348,"journal":{"name":"Problemy medycyny wieku rozwojowego","volume":"13 ","pages":"185-92"},"PeriodicalIF":0.0000,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Pharmacokinetics of nitrofurantoin in the bodies of pregnant rats].\",\"authors\":\"K Wierzba, B Wańkowicz, J Prokopczyk, A Piekarczyk\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The investigation of nitrofurantoin (NTF) pharmacokinetics in pregnant rats was undertaken to estimate its cumulation in the fetus unit. It was found that pharmacokinetics of NTF is dose-dependent in non-pregnant rats. The biological half-life time increased from 0.24 to 0.41 and 0.72 h for NTF doses 10.20 and 40 mg/kg, respectively. The elimination of NTF was diminished in pregnant rats. The pharmacokinetic analysis revealed a possibility of strong NTF accumulation in the pregnant rats (increased K12/K21 ratio). Taking into account increased renal function in pregnancy, one may suspect that decreased elimination of NTF was rather caused by its significant cumulation in the changed tissue compartment.</p>\",\"PeriodicalId\":76348,\"journal\":{\"name\":\"Problemy medycyny wieku rozwojowego\",\"volume\":\"13 \",\"pages\":\"185-92\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1984-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Problemy medycyny wieku rozwojowego\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Problemy medycyny wieku rozwojowego","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[Pharmacokinetics of nitrofurantoin in the bodies of pregnant rats].
The investigation of nitrofurantoin (NTF) pharmacokinetics in pregnant rats was undertaken to estimate its cumulation in the fetus unit. It was found that pharmacokinetics of NTF is dose-dependent in non-pregnant rats. The biological half-life time increased from 0.24 to 0.41 and 0.72 h for NTF doses 10.20 and 40 mg/kg, respectively. The elimination of NTF was diminished in pregnant rats. The pharmacokinetic analysis revealed a possibility of strong NTF accumulation in the pregnant rats (increased K12/K21 ratio). Taking into account increased renal function in pregnancy, one may suspect that decreased elimination of NTF was rather caused by its significant cumulation in the changed tissue compartment.
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