[Effect of histamine and its antagonists on the muscular tone of the non-pregnant uterus in the woman].

In the isolated strips of the individual parts of the human uterus (body, corns, cervix) histamine, promethazine, and cimethidine, proportionally to the dose applied, have proved to increase the muscular tonus. The blocking agents of histamine H-1 receptors (promethazine) and H-2 receptors (cimetidine), separately or jointly administered in the dose of 10 micrograms/ml, significantly diminish the tonicizing effect of histamine. The effect of histamine on the uterine muscular tonus is brought about through histamine H-1 and histamine H-2 receptors.