[蒽环类抗生素的心脏毒性作用]。

Bilten za hematologiju i transfuziju Pub Date : 1983-01-01
I Jovanović, L J Ceranić, S Simeunović, P Cvetković
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引用次数: 0

摘要

蒽环类抗生素(红霉素和阿霉素)常用于治疗急性白血病和各种实体瘤。这些药物的大剂量使用大多受到心肌损伤和心力衰竭的限制。本文讨论了红霉素对儿童急性白血病的心脏毒性分析。结果是通过对53例使用该药的患者进行调查得出的。他们根据给药的总剂量被分为亚组。6例患儿出现急性或慢性心肌损伤。亚组损伤发生率与给药总剂量成正比。
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[Cardiotoxic effect of anthracycline antibiotics].

Anthracycline antibiotic (Rubidomycin and Adriamycin) are often used for treatment of acute leukemia and variety of solid tumors. The use of greater doses of these agents is mostly limited by the damage of the cardiac muscle and by heart failure. The Rubidomycin cardiac toxicity analysis of children with acute leukemia has been considered in this paper. The results were obtained by investigating 53 patients who received this drug. They were classified in subgroups in relation to the total dose administered. Acute or chronic myocardial damage appeared in 6 children. The subgroup incidence of damage is directly proportional to the total dose administered.

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