{"title":"一种用线性回归确定两点情况下绑定参数的简化方法","authors":"Vincenzo Guardabasso , Fabio Benfenati","doi":"10.1016/0010-468X(83)90044-2","DOIUrl":null,"url":null,"abstract":"<div><p>A program using a simplified method to compute estimates of binding parameters in a system with two independent classes of binding sites is presented. An iterative method is used to approximate step-by-step the two lines describing the binding activities separately, starting from a curvilinear Scatchard or Hofstee plot. This method is designed for use on microcomputers with graphic facilities and on programmable hand-held calculators.</p></div>","PeriodicalId":75731,"journal":{"name":"Computer programs in biomedicine","volume":"17 3","pages":"Pages 235-242"},"PeriodicalIF":0.0000,"publicationDate":"1983-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0010-468X(83)90044-2","citationCount":"2","resultStr":"{\"title\":\"A simplified method to determine binding parameters in a two-site case using linear regression\",\"authors\":\"Vincenzo Guardabasso , Fabio Benfenati\",\"doi\":\"10.1016/0010-468X(83)90044-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A program using a simplified method to compute estimates of binding parameters in a system with two independent classes of binding sites is presented. An iterative method is used to approximate step-by-step the two lines describing the binding activities separately, starting from a curvilinear Scatchard or Hofstee plot. This method is designed for use on microcomputers with graphic facilities and on programmable hand-held calculators.</p></div>\",\"PeriodicalId\":75731,\"journal\":{\"name\":\"Computer programs in biomedicine\",\"volume\":\"17 3\",\"pages\":\"Pages 235-242\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1983-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0010-468X(83)90044-2\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Computer programs in biomedicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0010468X83900442\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Computer programs in biomedicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0010468X83900442","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A simplified method to determine binding parameters in a two-site case using linear regression
A program using a simplified method to compute estimates of binding parameters in a system with two independent classes of binding sites is presented. An iterative method is used to approximate step-by-step the two lines describing the binding activities separately, starting from a curvilinear Scatchard or Hofstee plot. This method is designed for use on microcomputers with graphic facilities and on programmable hand-held calculators.
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