{"title":"2,3,7,8-四氯二苯并呋喃对恒河猴的慢性毒性","authors":"W.P. McNulty, I. Pomerantz, T. Farrell","doi":"10.1016/0015-6264(81)90304-7","DOIUrl":null,"url":null,"abstract":"<div><p>2,3,7,8-Tetrachlorodibenzofuran (TCDF) at levels of 50 and 5 μg/kg (ppb) in food caused sickness and some deaths in groups of three rhesus macaques fed for 2 months and 6 months, respectively. The principal pathological changes were atrophy or squamous metaplasia of the sebaceous glands, mucous metaplasia and hyperplasia of the gastric mucosa; involution of the thymus and hypoplasia of the bone marrow. In animals that did not die during the experimental feeding, recovery was complete after 3 months of a TCDF-free diet.</p></div>","PeriodicalId":12197,"journal":{"name":"Food and cosmetics toxicology","volume":"19 ","pages":"Pages 57-63, 65"},"PeriodicalIF":0.0000,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0015-6264(81)90304-7","citationCount":"28","resultStr":"{\"title\":\"Chronic toxicity of 2,3,7,8-tetrachlorodibenzofuran for rhesus macaques\",\"authors\":\"W.P. McNulty, I. Pomerantz, T. Farrell\",\"doi\":\"10.1016/0015-6264(81)90304-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>2,3,7,8-Tetrachlorodibenzofuran (TCDF) at levels of 50 and 5 μg/kg (ppb) in food caused sickness and some deaths in groups of three rhesus macaques fed for 2 months and 6 months, respectively. The principal pathological changes were atrophy or squamous metaplasia of the sebaceous glands, mucous metaplasia and hyperplasia of the gastric mucosa; involution of the thymus and hypoplasia of the bone marrow. In animals that did not die during the experimental feeding, recovery was complete after 3 months of a TCDF-free diet.</p></div>\",\"PeriodicalId\":12197,\"journal\":{\"name\":\"Food and cosmetics toxicology\",\"volume\":\"19 \",\"pages\":\"Pages 57-63, 65\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1981-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0015-6264(81)90304-7\",\"citationCount\":\"28\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Food and cosmetics toxicology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0015626481903047\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food and cosmetics toxicology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0015626481903047","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Chronic toxicity of 2,3,7,8-tetrachlorodibenzofuran for rhesus macaques
2,3,7,8-Tetrachlorodibenzofuran (TCDF) at levels of 50 and 5 μg/kg (ppb) in food caused sickness and some deaths in groups of three rhesus macaques fed for 2 months and 6 months, respectively. The principal pathological changes were atrophy or squamous metaplasia of the sebaceous glands, mucous metaplasia and hyperplasia of the gastric mucosa; involution of the thymus and hypoplasia of the bone marrow. In animals that did not die during the experimental feeding, recovery was complete after 3 months of a TCDF-free diet.
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