I Joó, E S Stanislavsky, M I Zhvanetskaya, G M Mashilova, M A Gladus
{"title":"铜绿假单胞菌蛋白疫苗的主动和被动小鼠保护能力。","authors":"I Joó, E S Stanislavsky, M I Zhvanetskaya, G M Mashilova, M A Gladus","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Six different vaccines were prepared, each containing the soluble, practically lipopolysaccharide-free protein extract of 2 or 3 Pseudomonas aeruginosa strains. In active mouse protection tests the vaccines were shown to give protection against both homologous and heterologous serotype strains, and against strain PA-103 producing exotoxin A. In rabbits the vaccines were found to stimulate the production of protective antibodies demonstrable in a passive mouse protection test. The immune serum had a protective effect against the exotoxin A-producing strain PA-103, too. Toxicity of the vaccines was studied in mice (mouse weight gain test) and in rabbits (intracutaneous skin test and pyrogenicity). The vaccines were not or only slightly toxic.</p>","PeriodicalId":75387,"journal":{"name":"Acta microbiologica Academiae Scientiarum Hungaricae","volume":"29 4","pages":"267-75"},"PeriodicalIF":0.0000,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Active and passive mouse-protecting capacity of Pseudomonas aeruginosa protein vaccines.\",\"authors\":\"I Joó, E S Stanislavsky, M I Zhvanetskaya, G M Mashilova, M A Gladus\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Six different vaccines were prepared, each containing the soluble, practically lipopolysaccharide-free protein extract of 2 or 3 Pseudomonas aeruginosa strains. In active mouse protection tests the vaccines were shown to give protection against both homologous and heterologous serotype strains, and against strain PA-103 producing exotoxin A. In rabbits the vaccines were found to stimulate the production of protective antibodies demonstrable in a passive mouse protection test. The immune serum had a protective effect against the exotoxin A-producing strain PA-103, too. Toxicity of the vaccines was studied in mice (mouse weight gain test) and in rabbits (intracutaneous skin test and pyrogenicity). The vaccines were not or only slightly toxic.</p>\",\"PeriodicalId\":75387,\"journal\":{\"name\":\"Acta microbiologica Academiae Scientiarum Hungaricae\",\"volume\":\"29 4\",\"pages\":\"267-75\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1982-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta microbiologica Academiae Scientiarum Hungaricae\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta microbiologica Academiae Scientiarum Hungaricae","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Active and passive mouse-protecting capacity of Pseudomonas aeruginosa protein vaccines.
Six different vaccines were prepared, each containing the soluble, practically lipopolysaccharide-free protein extract of 2 or 3 Pseudomonas aeruginosa strains. In active mouse protection tests the vaccines were shown to give protection against both homologous and heterologous serotype strains, and against strain PA-103 producing exotoxin A. In rabbits the vaccines were found to stimulate the production of protective antibodies demonstrable in a passive mouse protection test. The immune serum had a protective effect against the exotoxin A-producing strain PA-103, too. Toxicity of the vaccines was studied in mice (mouse weight gain test) and in rabbits (intracutaneous skin test and pyrogenicity). The vaccines were not or only slightly toxic.