铜绿假单胞菌蛋白疫苗的主动和被动小鼠保护能力。

I Joó, E S Stanislavsky, M I Zhvanetskaya, G M Mashilova, M A Gladus
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引用次数: 0

摘要

制备了六种不同的疫苗,每种疫苗含有2或3种铜绿假单胞菌菌株的可溶性,实际上不含脂多糖的蛋白质提取物。在小鼠主动保护试验中,疫苗显示出对同源和异源血清型菌株以及产生外毒素a的PA-103菌株的保护作用。在家兔中,疫苗被发现能刺激保护性抗体的产生,这在小鼠被动保护试验中得到证实。免疫血清对产外毒素a的菌株PA-103也有保护作用。在小鼠(小鼠增重试验)和家兔(皮内皮肤试验和热原性试验)中研究了疫苗的毒性。这些疫苗没有毒性,或者只有轻微毒性。
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Active and passive mouse-protecting capacity of Pseudomonas aeruginosa protein vaccines.

Six different vaccines were prepared, each containing the soluble, practically lipopolysaccharide-free protein extract of 2 or 3 Pseudomonas aeruginosa strains. In active mouse protection tests the vaccines were shown to give protection against both homologous and heterologous serotype strains, and against strain PA-103 producing exotoxin A. In rabbits the vaccines were found to stimulate the production of protective antibodies demonstrable in a passive mouse protection test. The immune serum had a protective effect against the exotoxin A-producing strain PA-103, too. Toxicity of the vaccines was studied in mice (mouse weight gain test) and in rabbits (intracutaneous skin test and pyrogenicity). The vaccines were not or only slightly toxic.

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