左心房受体刺激利尿:促肾上腺皮质激素与马氏小管。

M F Knapp, R J Linden, M J Pearson
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引用次数: 2

摘要

刺激左心房受体引起利尿,部分是通过血源性药物引起的。马氏小管在利尿过程中可检测血源性病原体。有人认为这种作用是ADH,但这是有争议的。在本研究中,我们发现加压素(1-300 mu iu cm-3)加入血浆、罗德涅耳林格和罗德涅耳林格+ 5-HT后,对马氏小管分泌没有影响。此外,研究表明,在左心房腔内膨胀球囊刺激心房受体之前和期间,用巯基乙酸钠孵育麻醉犬的血浆样本,并不能消除马氏小管检测到的试验血浆样本与对照血浆样本之间的差异。由此可见,与左心房刺激引起的利尿有关的马尔比氏小管检测到的血浆差异与ADH浓度的变化无关。
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Diuresis from stimulation of left atrial receptors: ADH and the Malpighian tubules of Rhodnius prolixus.

Stimulation of left atrial receptors causes a diuresis partly through a blood borne agent. Malpighian tubules of Rhodnius prolixus can detect a blood borne agent during the diuresis. It has been suggested that the agent is ADH but this is in dispute. In the present investigation, vasopressin (1-300 mu i.u. cm-3) was found to have no effect on Malpighian tubule secretion when added to plasma, Rhodnius Ringer and Rhodnius Ringer + 5-HT. In addition, it was shown that incubation with sodium thioglycollate of plasma samples obtained from anaesthetized dogs, before and during stimulation of atrial receptors by distension of a balloon in the lumen of the left atrium, did not abolish the differences between test and control plasma samples detected by the Malpighian tubules. It is concluded that differences in plasma detected by the Malpighian tubules and related to the diuresis which results from left atrial stimulation are not attributable to changes in concentration of ADH.

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