K B Grabovskaya, A A Totoljan, M Rýc, J Havlícek, L A Burova, R Bícová
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Adherence of group A streptococci to epithelial cells in tissue culture.
Using the HEp-2 cell line system the factors and mechanisms of group A Streptococcus adherence had been studied. It was shown that high adherence was chiefly found in strains showing attributes of virulence (presence of M protein, growth in human blood, lethality for mice). The data supplied by experiments with pepsin and LTA suggest that there exist at least two mechanisms of adherence.