氯丙帕明与阿米替林治疗强迫神经症的双盲比较研究

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI:10.1016/0364-7722(81)90077-1

Jambur Ananth , John C. Pecknold , Nancy Van Den Steen , Frank Engelsmann

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引用次数: 137

摘要

1.1. 通过为期四周的随机双盲试验，比较盐酸氯米帕明与阿米替林治疗重度强迫性神经症(OCN)的疗效。在强迫症状、抑郁和焦虑方面，氯丙帕明而阿米替林没有显著改善。阿米替林对焦虑和抑郁缺乏显著作用可能是由于其不能改善原发性强迫症状。两组均未见严重不良反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Double-blind comparative study of clomipramine and amitriptyline in obsessive neurosis

1.
1. The efficacy of clomipramine hydrochloride in severe obsessive compulsive neurosis (OCN) was compared with that of amitriptyline in a four week randomized double-blind trial.
2.
2. Clomipramine but not amitriptyline produced statistically significant improvement in the obsessive symptoms, depression and anxiety.
3.
3. The lack of significant effect of amitriptyline on anxiety and depression may be due to its inability to improve the primary obsessive symptoms.
4.
4. No serious adverse effects were encountered in either drug group.

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