低剂量环孢素A对淋巴细胞的激活作用。

Acta biologica et medica Germanica Pub Date : 1982-01-01

C Diener, D Haroske, G Metzner, L Jäger

{"title":"低剂量环孢素A对淋巴细胞的激活作用。","authors":"C Diener, D Haroske, G Metzner, L Jäger","doi":"","DOIUrl":null,"url":null,"abstract":"Supernatants of human lymphocyte cultures incubated with cyclosporin A (CS-A) for 90 min reveal an inhibitory effect on the electrophoretic mobility of guinea-pig macrophages. This effect is distinctly demonstrable already at CS-A concentrations from 10-7 micrograms/ml on with a maximum at 10-3 micrograms/ml. An inhibitory action of CS-A on PHA-induced lymphocyte proliferation is detectable only beyond 10-2 micrograms/ml CS-A. The CS-A induced lymphokine is comparable to that stimulated by other ways (PHA, ConA).","PeriodicalId":6985,"journal":{"name":"Acta biologica et medica Germanica","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Lymphocyte activation by low doses of cyclosporin A.\",\"authors\":\"C Diener, D Haroske, G Metzner, L Jäger\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Supernatants of human lymphocyte cultures incubated with cyclosporin A (CS-A) for 90 min reveal an inhibitory effect on the electrophoretic mobility of guinea-pig macrophages. This effect is distinctly demonstrable already at CS-A concentrations from 10-7 micrograms/ml on with a maximum at 10-3 micrograms/ml. An inhibitory action of CS-A on PHA-induced lymphocyte proliferation is detectable only beyond 10-2 micrograms/ml CS-A. The CS-A induced lymphokine is comparable to that stimulated by other ways (PHA, ConA).\",\"PeriodicalId\":6985,\"journal\":{\"name\":\"Acta biologica et medica Germanica\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1982-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta biologica et medica Germanica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta biologica et medica Germanica","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

环孢素A (cyclosporin A, CS-A)培养90 min的人淋巴细胞上清对豚鼠巨噬细胞的电泳迁移率有抑制作用。在CS-A浓度从10-7微克/毫升到10-3微克/毫升的最大值时，这种效应已经明显地被证明。CS-A对pha诱导的淋巴细胞增殖的抑制作用仅在10-2微克/毫升CS-A时检测到。CS-A诱导的淋巴因子与其他方式刺激的淋巴因子相当(PHA, ConA)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Lymphocyte activation by low doses of cyclosporin A.

Supernatants of human lymphocyte cultures incubated with cyclosporin A (CS-A) for 90 min reveal an inhibitory effect on the electrophoretic mobility of guinea-pig macrophages. This effect is distinctly demonstrable already at CS-A concentrations from 10-7 micrograms/ml on with a maximum at 10-3 micrograms/ml. An inhibitory action of CS-A on PHA-induced lymphocyte proliferation is detectable only beyond 10-2 micrograms/ml CS-A. The CS-A induced lymphokine is comparable to that stimulated by other ways (PHA, ConA).

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Acta biologica et medica Germanica

自引率

0.00%

发文量