{"title":"乙醇诱导断奶C57BL/6J小鼠对听源性癫痫发作的短暂易感性。","authors":"R A Schreiber","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>An acute dose of 5 g/kg ethanol led to a transient few days of a low incidence of susceptibility to audiogenic seizures in C57BL/6J mice (normally not susceptible) if the ethanol was administered during the transition from suckling to dietary self-sufficiency. This demonstrates a critical period of responsiveness to ethanol, shows ethanol-induced audiogenic priming, and may provide evidence for an indirect effect of ethanol on the brain.</p>","PeriodicalId":22076,"journal":{"name":"Substance and alcohol actions/misuse","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ethanol induces a transient susceptibility to audiogenic seizures in weanling C57BL/6J mice.\",\"authors\":\"R A Schreiber\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>An acute dose of 5 g/kg ethanol led to a transient few days of a low incidence of susceptibility to audiogenic seizures in C57BL/6J mice (normally not susceptible) if the ethanol was administered during the transition from suckling to dietary self-sufficiency. This demonstrates a critical period of responsiveness to ethanol, shows ethanol-induced audiogenic priming, and may provide evidence for an indirect effect of ethanol on the brain.</p>\",\"PeriodicalId\":22076,\"journal\":{\"name\":\"Substance and alcohol actions/misuse\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1982-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Substance and alcohol actions/misuse\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Substance and alcohol actions/misuse","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Ethanol induces a transient susceptibility to audiogenic seizures in weanling C57BL/6J mice.
An acute dose of 5 g/kg ethanol led to a transient few days of a low incidence of susceptibility to audiogenic seizures in C57BL/6J mice (normally not susceptible) if the ethanol was administered during the transition from suckling to dietary self-sufficiency. This demonstrates a critical period of responsiveness to ethanol, shows ethanol-induced audiogenic priming, and may provide evidence for an indirect effect of ethanol on the brain.
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