去甲替林逆转习得性无助

J.I. Telner, R.L. Singhal, Y.D. Lapierre
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引用次数: 21

摘要

1.1. 面对不可避免的压力的动物在随后的任务情境中表现出逃避和逃避缺陷,成功的反应导致压力抵消,这种现象被称为习得性无助。这种模式被认为是抑郁症的动物模型,因为它具有人类疾病的许多特征。先前在小鼠身上显示出干扰效应的逃逸延迟过程在大鼠身上重现。使用这种逃避延迟程序,评估急性和亚急性给药去甲替林对习得性无助行为的影响。4天和6天的药物治疗逆转了暴露于休克前的动物产生的逃避缺陷,而0天和2天的药物治疗没有效果。这些发现支持了习得性无助模型在评估抗抑郁药物在实验动物中的潜力方面的效用。
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Reversal of learned helplessness by nortriptyline

  • 1.

    1. Animals exposed to inescapable stress display avoidance and escape deficits when tested in a later task situation where successful responding results in stress offset, a phenomenon termed learned helplessness. This paradigm has been suggested as an animal model of depression as it shares many of the characteristics of the human disorder.

  • 2.

    2. An escape delay procedure previously shown to reveal interference effects in mice was reproduced in rats.

  • 3.

    3. Using this escape delay procedure, the effects of acute and sub-acute administration of nortriptyline on learned helplessness behavior were assessed.

  • 4.

    4. Four and 6 days of drug treatment reversed the escape deficits produced in animals exposed to pre-shock whereas the 0 and 2 day drug regimens were without effect.

  • 5.

    5. These findings support the utility of the learned helplessness model in evaluating the potential of antidepressant agents in experimental animals.

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