精神药物对仓鼠冬眠影响的初步研究

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI:10.1016/0364-7722(81)90055-2

Peter Zvolsky , Libor Jansky , Jana Vyskocilova , Paul Grof

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引用次数: 10

摘要

1.1. 昼夜节律和周期节律的不同步可能在原发性情感性障碍中起重要作用。在主要情感障碍和冬眠之间发现了有趣的生化和解剖学上的相似之处。冬眠是一种周期性的年际活动，主要由内部和遗传因素决定，也受环境刺激的影响。我们将冬眠作为周期性事件的动物模型，研究了精神药物对金仓鼠冬眠的影响。在这个范例中，丙咪嗪明显干扰冬眠过程，并导致冬眠前时间的显著延长。由于方法学上的问题，锂试验的结果无法解释。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Effects of psychotropic drugs on hamster hibernation—pilot study

1.
1. The desynchronization of circadian and circannual rhythms may play an important role in primary affective disorders.
2.
2. Interesting biochemical as well as anatomical parallels have been found between primary affective disorders and hibernation.
3.
3. Hibernation is a periodic circannual event which is determined mainly by internal and hereditary factors, and influenced also by environmental stimuli. We employed hibernation as an animal model of periodic events and studied the effect of psychotropic drugs on hibernation in the golden hamster.
4.
4. In this paradigm imipramine clearly interfered with the hibernating process and caused significant prolongation of the prehibernation period. The results of lithium trial could not be interpreted because of methodological problems.

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