n -双-(2-羟丙基)亚硝胺对新生大鼠的致癌作用

Experimentelle Pathologie Pub Date : 1980-01-01 DOI:10.1016/S0014-4908(80)80063-9

Y. Konishi, T. Ikeda, A. Kawabata, H. Katada, K. Higashiguchi, H. Maruyama, H. Yoshimura

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引用次数: 6

摘要

研究了n -双(2-羟丙基)亚硝胺(BHP)对新生Wistar大鼠的致癌作用。治疗后24周肺(腺瘤)、胰腺(腺瘤)、肾脏(肾母细胞瘤)、卵巢(良性颗粒细胞瘤)诱导肿瘤，治疗后52周肺(腺瘤、腺癌)、肝脏(血管瘤、血管内皮瘤、肝细胞癌)、胰腺(腺瘤)、肾脏(肾细胞癌、肾母细胞瘤)、甲状腺(腺癌)、卵巢(良性、恶性颗粒细胞瘤)诱导肿瘤。出生后24小时内应用BHP的大鼠肝脏肿瘤发生率最高。这些结果表明，新生Wistar大鼠比成年大鼠更容易发生BHP。

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Carcinogenic effect of N-bis-(2-hydroxypropyl)nitrosamine in newborn rats

The carcinogenic effect of N-bis(2-hydroxypropyl)nitrosamine (BHP) was studied in newborn Wistar rats. Tumors were induced in the lung (adenoma), pancreas (adenoma), kidney (nephroblastoma), and ovary (benign granulosa cell tumor) at 24 weeks after the treatment and in the lung (adenoma and adenocarcinoma), liver (hemangioma, hemangioendothelioma, and hepatocellular carcinoma), pancreas (adenoma), kidney (renal cell carcinoma and nephroblastoma), thyroid (adenocarcinoma) and ovary (benign and malignant granulosa cell tumors) at 52 weeks. The highest incidence of tumor was seen in the liver of rats applied BHP within 24 hours after birth.

These results indicate that newborn Wistar rats are more susceptible to BHP than are adult rats.

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