Morphological changes of ovarian follicles of guinea pigs bred on a low calcium diet

In previous investigations we could demonstrate that angiitis or angiolytic changes of the vascular wall with loosening or duplication of the basement membrane may be caused by a low calcium diet. In this paper we present experiments using the same experimental procedures which lead to massive necrotic changes of granulosa cells in the ovary. These phenomena are thought to be induced by loosening and swelling of the basement membrane which delimits the granulosa layers from the outermost tissue.