{"title":"秀丽隐杆线虫转座因子Tc1的年龄依赖性体细胞切除","authors":"Nejat K. Egilmez, Robert J. Shmookler Reis","doi":"10.1016/0921-8734(94)90004-3","DOIUrl":null,"url":null,"abstract":"<div><p>The Tc1 element of the free-living nematode <em>Caenorhabditis elegans</em> is a well characterized transposon that is present in 30–500 copies per haploid genome, depending on the strain. Excision of Tc1 elements, which occurs readily in somatic tissues during larval development, has not previously been examined during aging of adult worms. We have identified a recently inserted Tc1 element in the KR1787 mutator strains of <em>C. elegans</em> and have found that Tc1 somatic excision at that site increases by more than 14-fold during the organism's lifespan.</p></div>","PeriodicalId":100937,"journal":{"name":"Mutation Research/DNAging","volume":"316 1","pages":"Pages 17-24"},"PeriodicalIF":0.0000,"publicationDate":"1994-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0921-8734(94)90004-3","citationCount":"16","resultStr":"{\"title\":\"Age-dependent somatic excision of transposable element Tc1 in Caernohabditis elegans\",\"authors\":\"Nejat K. Egilmez, Robert J. Shmookler Reis\",\"doi\":\"10.1016/0921-8734(94)90004-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The Tc1 element of the free-living nematode <em>Caenorhabditis elegans</em> is a well characterized transposon that is present in 30–500 copies per haploid genome, depending on the strain. Excision of Tc1 elements, which occurs readily in somatic tissues during larval development, has not previously been examined during aging of adult worms. We have identified a recently inserted Tc1 element in the KR1787 mutator strains of <em>C. elegans</em> and have found that Tc1 somatic excision at that site increases by more than 14-fold during the organism's lifespan.</p></div>\",\"PeriodicalId\":100937,\"journal\":{\"name\":\"Mutation Research/DNAging\",\"volume\":\"316 1\",\"pages\":\"Pages 17-24\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1994-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0921-8734(94)90004-3\",\"citationCount\":\"16\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Mutation Research/DNAging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0921873494900043\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mutation Research/DNAging","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0921873494900043","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Age-dependent somatic excision of transposable element Tc1 in Caernohabditis elegans
The Tc1 element of the free-living nematode Caenorhabditis elegans is a well characterized transposon that is present in 30–500 copies per haploid genome, depending on the strain. Excision of Tc1 elements, which occurs readily in somatic tissues during larval development, has not previously been examined during aging of adult worms. We have identified a recently inserted Tc1 element in the KR1787 mutator strains of C. elegans and have found that Tc1 somatic excision at that site increases by more than 14-fold during the organism's lifespan.
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