[24R,25-二羟维生素D3对去垂体大鼠肾脏碱性磷酸酶和γ -谷氨酰转移酶的体内影响]。

Archives internationales de physiologie, de biochimie et de biophysique Pub Date : 1993-11-01 DOI:10.3109/13813459309046994

T X Do, A Girault, M Prelot

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摘要

研究了24R, 25-二羟基维生素D3 (24,25 (OH)2 D3)对垂体去骨(Hx)大鼠肾皮质碱性磷酸酶(ALP)、γ -谷氨酰转移酶(GGT)和酸性磷酸酶(ACP)活性的影响。腹腔注射第二类固醇(10 pmol /100 g体重)3、6和12小时后，与对照组相比，ALP活性分别提高了+27、+56和+60%。GGT活性刺激仅在6 h(+30%)和12 h(+ 46%)后开始。ACP活性未改变。在体内，两种酶对Hx大鼠肾脏的诱导作用均高于体外，且时间较长。

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[In vivo effects of 24R,25-dihydroxyvitamin D3 on kidney alkaline phosphatase and gamma-glutamyltransferase of hypophysectomized rats].

The effects of 24R, 25-dihydroxyvitamin D3 (24, 25 (OH)2 D3) on alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT) and acid phosphatase (ACP) activities were investigated on renal cortex of hypophysectomized (Hx) rats. ALP activity was increased by +27, +56 and +60% as compared to controls respectively 3, 6 and 12 h after intraperitoneal administration of the secosteroid (10 pmoles/100 g body weight). Stimulations of GGT activity began only after 6 h (+30%) and 12 h (+ 46%). ACP activity was not modified. In vivo, the two enzymatic inductions in kidneys of Hx rats were higher and longer than those obtained in vitro.

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Archives internationales de physiologie, de biochimie et de biophysique

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