环卡前列素可抑制胶原诱导的大鼠肺血小板聚集数小时。

Agents and actions. Supplements Pub Date : 1995-01-01 DOI:10.1007/978-3-0348-7346-8_15

G Nowak, E Bucha

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引用次数: 0

摘要

介绍了一种直接定量测定大鼠肺胶原诱导血小板捕获的新方法。合成的PG1(2)模拟物Iloprost和Cicaprost能够抑制胶原诱导的血小板捕获。所描述的方法已被证明适用于对胶原诱导的血小板捕获抑制剂进行药效学和效应动力学研究。

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Cicaprost inhibits collagen-induced platelet accumulation in rat lungs for some hours.

A new method is introduced admitting of direct quantification of collagen-induced platelet trapping in the rat lung. The synthetic PG1(2)-mimetics, Iloprost and Cicaprost, are capable of inhibiting the trapping of platelets induced by collagen. The described method has proved to be suited for performing both pharmacodynamic and effectkinetic investigations with inhibitors of collagen-induced platelet trapping.

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Agents and actions. Supplements

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