Liesl De Sevilla , Sylvia A. McCune , Michael E. White
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Insulin-like growth factor mRNA expression in tissues of lean and obese male SHFF/Mcc-facp rats
No differences were detected in serum IGF-I levels between lean and obese male SHFF/Mcc-facp rats expressing non-insulin-dependent diabetes mellitus (NIDDM). In contrast, serum insulin levels, and blood glucose levels were significantly elevated in obese as compared to lean littermates (P < 0.05), indicating that the obese animals were diabetic. Northern blot analyses of total tissue RNA using labeled cDNAs for IGF-I and IGF-II revealed a decrease in liver and adipose IGF-I mRNA expression in the obese littermates while IGF-II mRNA expression was decreased only in adipose tissue of obese animals as compared to lean littermates.
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