[CD7+CD4-CD8-急性白血病免疫表型异质性]。

IF 0.2 4区医学 Q4 HEMATOLOGY Gematologiya I Transfuziologiya Pub Date : 1995-07-01

I V Abramenko, N I Belous, L M Skliarenko, V A Nadgornaia

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引用次数: 0

摘要

研究了14例淋巴和髓性急性白血病(AL)在胚细胞上CD7抗原的表达，CD7抗原是T谱系分化早期发现的细胞表面标记物。CD7+ CD4-CD8- AL的异质组包括不同的细胞学亚变体:髓系(AML, MO, M1, M4, M5)和淋巴(t细胞前)承诺，双表型或混合谱系AL和AL，具有最小的原始细胞分化迹象，似乎不受谱系限制。AL的后一个子集可能代表谱系承诺之前的早期干细胞的转化对应物。

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[Immunophenotypic heterogeneity of CD7+CD4-CD8--acute leukemia].

Fourteen cases of lymphoid and myeloid acute leukemia (AL) were studied for expression on blast cells of CD7 antigen, a cell surface marker found early during T lineage differentiation. This heterogenic group of CD7+ CD4-CD8- AL includes distinct cytological subvariants with: myeloid (AML MO, M1, M4, M5) and lymphoid (pre-T-cell) commitment, biphenotypic or mixed lineage AL and AL with minimal signs of blast cell differentiation, which appear not to follow lineage restriction. The latter subset of AL may represent the transformed counterpart of an early stem cell prior to lineage commitment.

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来源期刊

Gematologiya I Transfuziologiya 医学-血液学

CiteScore

0.80

自引率

66.70%

发文量

审稿时长

>12 weeks

期刊介绍： The journal publishes original theoretical and clinical studies, lectures, reviews, and practical notes concerning various problems of hematology and clinical and industrial transfusion. The journal provides information on the etiology, pathogenesis, diagnosis and treatment of blood disorders as well as on related non-hematological conditions (internal diseases, poisoning, exposure to ionizing radiation etc.).