{"title":"衰老对9种小鼠外周血自发微核频率的影响:CSGMT/JEMS·MMS第七次合作研究结果","authors":"Sci-ichi Sato , Masako Taketomi , Madoka Nakajima , Michiyo Kitazawa , Hiroyasu Shimada , Satoru Itoh , Miyuki Igarashi , Naohiko Higashikuni , Shizuyo Sutou , Yu F. Sasaki , Makoto Hayashi , Toshio Sofuni , Takafumi Higashiguchi , Shinji Nito , Yasushi Kondo , Sachiko Honda , Mikiko Hayashi , Yasuhiro Shinagawa , Eiichi Nakajima , Yoshie Oka , Koichi Tamai","doi":"10.1016/0921-8734(95)00011-T","DOIUrl":null,"url":null,"abstract":"<div><p>The spontaneous frequencies of micronucleated reticulocytes (MNRETs) were examined monthly over the life spans of animals belonging to nine mouse strains for the 7th collaborative study organized by the CSGMT/JEMS MMS. Both sexes of the BDF1 strain and females of the A/J strain showed a statistically significant increase in mean spontaneous MNRET frequency in their last month of life, suggesting the possibility of strain-specific, age-dependent chromosomal instability. SAMP6/Tan, an accelerated senescence-prone strain, showed the same tendency, although it was not statistically significant. The other strains studied, ddY, CD-1, B6C3F1, SAMR1, and MS/Ac, did not show significant age-related differences in mean of MNRET frequencies. More extensive statistical analyses are underway, and the outcomes will be reported separately.</p></div>","PeriodicalId":100937,"journal":{"name":"Mutation Research/DNAging","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1995-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0921-8734(95)00011-T","citationCount":"27","resultStr":"{\"title\":\"Effect of aging on spontaneous micronucleus frequencies in peripheral blood of nine mouse strains: the results of the 7th collaborative study organized by CSGMT/JEMS · MMS\",\"authors\":\"Sci-ichi Sato , Masako Taketomi , Madoka Nakajima , Michiyo Kitazawa , Hiroyasu Shimada , Satoru Itoh , Miyuki Igarashi , Naohiko Higashikuni , Shizuyo Sutou , Yu F. Sasaki , Makoto Hayashi , Toshio Sofuni , Takafumi Higashiguchi , Shinji Nito , Yasushi Kondo , Sachiko Honda , Mikiko Hayashi , Yasuhiro Shinagawa , Eiichi Nakajima , Yoshie Oka , Koichi Tamai\",\"doi\":\"10.1016/0921-8734(95)00011-T\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The spontaneous frequencies of micronucleated reticulocytes (MNRETs) were examined monthly over the life spans of animals belonging to nine mouse strains for the 7th collaborative study organized by the CSGMT/JEMS MMS. Both sexes of the BDF1 strain and females of the A/J strain showed a statistically significant increase in mean spontaneous MNRET frequency in their last month of life, suggesting the possibility of strain-specific, age-dependent chromosomal instability. SAMP6/Tan, an accelerated senescence-prone strain, showed the same tendency, although it was not statistically significant. The other strains studied, ddY, CD-1, B6C3F1, SAMR1, and MS/Ac, did not show significant age-related differences in mean of MNRET frequencies. More extensive statistical analyses are underway, and the outcomes will be reported separately.</p></div>\",\"PeriodicalId\":100937,\"journal\":{\"name\":\"Mutation Research/DNAging\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1995-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0921-8734(95)00011-T\",\"citationCount\":\"27\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Mutation Research/DNAging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/092187349500011T\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mutation Research/DNAging","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/092187349500011T","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effect of aging on spontaneous micronucleus frequencies in peripheral blood of nine mouse strains: the results of the 7th collaborative study organized by CSGMT/JEMS · MMS
The spontaneous frequencies of micronucleated reticulocytes (MNRETs) were examined monthly over the life spans of animals belonging to nine mouse strains for the 7th collaborative study organized by the CSGMT/JEMS MMS. Both sexes of the BDF1 strain and females of the A/J strain showed a statistically significant increase in mean spontaneous MNRET frequency in their last month of life, suggesting the possibility of strain-specific, age-dependent chromosomal instability. SAMP6/Tan, an accelerated senescence-prone strain, showed the same tendency, although it was not statistically significant. The other strains studied, ddY, CD-1, B6C3F1, SAMR1, and MS/Ac, did not show significant age-related differences in mean of MNRET frequencies. More extensive statistical analyses are underway, and the outcomes will be reported separately.
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