Yuen-Li Chung , Alun Williams , John S. Beech , Steve C.R. Williams , Jimmy D. Bell , Jane I. Cox , James Hope
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MRI Assessment of the Blood-Brain Barrier in a Hamster Model of Scrapie
Magnetic resonance (MR) imaging in combination with gadolinium-diethylenetriaminepenta-acetic acid (Gd-DTPA) enhancement was used to investigate the integrity of the blood-brain barrier in a hamster model of scrapie (263K) during the clinical phase of the disease. The post Gd-DTPA images of the infected hamster brain showed marked enhancement, which was not present in control animals. These results suggest that blood-brain barrier function is disrupted in the clinically-affected animal.
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