大肠杆菌中的新基因dinP,其产物与UmuC及其同源物相似

Haruo Ohmori , Eriko Hatada , Ying Qiao , Mariko Tsuji , Ryuji Fukuda
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引用次数: 67

摘要

在大肠杆菌5.5 min区域的基因组测序中发现了一个新的基因,命名为dinP。它的编码区前面有一个序列,类似于LexA的共识绑定序列,即所谓的SOS盒序列。DinP(351个氨基酸残基)的氨基酸序列与秀丽隐杆线虫的假设蛋白F22B7.6有很强的相似性,与大肠杆菌和鼠伤寒沙门氏菌的UmuC同源物以及酿酒酵母的REV1有较弱的相似性。另一个SOS操纵子(dinJ1和dinJ2基因)也在这个区域被发现。
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dinP, a new gene in Escherichia coli, whose product shows similarities to UmuC and its homologues

A new gene, designated dinP, was found during E. coli genomic sequencing around the 5.5 min region. Its coding region is preceded by a sequence similar to the consensus binding sequence for LexA, the so-called SOS box sequence. The amino acid sequence of DinP (351 amino acid residues) has a strong similarity to the C. elegans hypothetical protein F22B7.6 and weaker similarities to the UmuC homologues in E. coli and Salmonella typhimurium and also to REV1 of Saccharomyces cerevisiae. Another SOS operon (dinJ1 and dinJ2 genes) found in this region is also described.

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