体内对白细胞介素-6的内分泌和碳水化合物反应。

Circulatory shock Pub Date : 1994-12-01
R D Stith, J Luo
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引用次数: 0

摘要

除了抑制肝磷酸烯醇丙酮酸羧激酶外,白细胞介素-6 (IL-6)在碳水化合物代谢中的作用尚未得到广泛的研究。为了描述IL-6的作用,我们在大鼠体内检测了静脉注射重组人IL-6后30、60、90、120和180分钟血浆皮质酮、胰高血糖素、胰岛素和葡萄糖水平以及肝糖原含量的反应。增加血浆皮质酮的作用与众所周知的IL-6对下丘脑-垂体-肾上腺皮质的作用一致。IL-6产生血浆胰高血糖素的短暂增加,这反映在血浆葡萄糖升高和肝糖原的消耗上。血浆胰岛素水平在注射IL-6后1小时内未升高,但在注射后90分钟及以后显著升高。我们认为刺激循环胰岛素增加的是血浆葡萄糖升高,而不是IL-6的直接作用。结果表明,直接作用于外周器官和/或通过中枢神经系统(CNS)的IL-6可以改变激素和碳水化合物环境。我们认为IL-6的这些作用是其在急性期反应中作用的一个方面。
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Endocrine and carbohydrate responses to interleukin-6 in vivo.

The role of interleukin-6 (IL-6) in carbohydrate metabolism beyond its inhibition of hepatic phosphoenolpyruvate carboxykinase has not been widely pursued. To describe such IL-6 effects, we examined in the rat the responses of plasma corticosterone, glucagon, insulin, and glucose levels and the hepatic glycogen content 30, 60, 90, 120, and 180 min after intravenous injection of recombinant human IL-6. The effect to increase plasma corticosterone was consonant with the well-known action of IL-6 on the hypothalamus-pituitary-adrenal cortex. IL-6 produced a transient increase in plasma glucagon that was mirrored by elevated plasma glucose and a depletion of hepatic glycogen. Plasma insulin levels were not elevated within the first hour after IL-6 injection but were significantly elevated 90 min and beyond. We suggest that the stimulus for increased circulating insulin was elevated plasma glucose, rather than a direct effect of IL-6. The results demonstrate that IL-6, acting directly on peripheral organs and/or through the central nervous system (CNS) can alter the hormonal and carbohydrate milieu. We propose that these actions of IL-6 are one aspect of its role in the acute phase response.

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