GABAA受体的神经活性类固醇调节。

R W Olsen, D W Sapp
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引用次数: 0

摘要

总之,神经活性类固醇的发现导致了对内分泌-神经系统相互作用的新认识。类固醇激素代谢物对GABAA受体的调节具有深远的生理和药理学意义,包括与人类精神和神经问题相关(图7):1 .全麻(Alphaxalone)机制2。某些区域(如尾状核)的GABA音调抗焦虑活动:(产后抑郁、经前综合症?)(新药?)四、分娩五、抗癫痫活性(新药?)区域异质性(受体亚型)部分激动剂(更好的临床表现?)图7所示。GABAA受体作为类固醇非基因组中枢神经系统靶点的意义。
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Neuroactive steroid modulation of GABAA receptors.

In summary, the discovery of neuroactive steroids has led to a new appreciation of endocrine-nervous system interactions. The modulation of GABAA receptors by steroid hormone metabolites has far-reaching physiological and pharmacological implications, including relevance to human psychiatric and neurological problems (Fig. 7): I. MECHANISM OF GENERAL ANESTHESIA (Alphaxalone) II. GABA TONE IN SOME REGIONS (e.g., caudate) III. ANTI-ANXIETY ACTIVITY: (Post-partum depression, premenstrual syndrome?) (New drugs?) IV. CHILDBIRTH V. ANTIEPILEPTIC ACTIVITY (New drugs?) VI. REGIONAL HETEROGENEITY (Receptor subtypes) VII. PARTIAL AGONISTS (Better clinical profile?) FIG. 7. Implications of GABAA receptor as a nongenomic CNS target of steroids.

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