肝对血浆钾化钾素和血浆钾化钾素- α -巨球蛋白复合物清除率的比较。

H Ogata, M Kouyoumdjian, D R Borges
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引用次数: 9

摘要

1. 采用凝胶过滤和超离心两阶段法从损伤大鼠血清中分离α -巨球蛋白(α Ms)。2. 在离体大鼠肝脏灌注系统中比较了大鼠血浆钾激肽(RPK)和α Ms-RPK复合物的清除率:α Ms-RPK复合物的清除率(半衰期从24到> 120分钟)比RPK本身(半衰期从13到18分钟)慢得多。
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Comparison between clearance rates of plasma kallikrein and of plasma kallikrein-alpha-macroglobulin complexes by the liver.

1. alpha-Macroglobulins (alpha Ms) were isolated from the serum of injured rats through a two-stage method: gel filtration and ultracentrifugation. 2. The clearance rates of rat plasma kallikrein (RPK) and alpha Ms-RPK complexes were compared in an isolated rat liver perfusion system: the alpha Ms-RPK complexes are cleared at a much slower rate (half-life ranging from 24 to > 120 min) than does RPK itself (half-life ranging from 13 to 18 min).

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