{"title":"罗伊特素及其与舒拉明、美拉胂醇、dl-α-二氟甲基鸟氨酸和博来霉素联合治疗小鼠感染布鲁氏锥虫的体内评价","authors":"Manasses K. Yunmbam, John F. Roberts","doi":"10.1016/0742-8413(93)90095-3","DOIUrl":null,"url":null,"abstract":"<div><p>1. <em>Trypanosoma brucei brucei</em> -infected mouse models treated with a new antibiotic, reuterin, showed reduction of the levels of parasitemia and prolonged survival of the mice.</p><p>2. Cures of the parasitemia were observed in groups of mice treated with combinations of reuterin and suramin or melarsoprol.</p><p>3. Reuterin administered in combination with bleomycin or <span>dl</span>-α-difluoromethylornithine showed temporary remission of the parasitemia in groups of mice.</p></div>","PeriodicalId":72650,"journal":{"name":"Comparative biochemistry and physiology. C: Comparative pharmacology","volume":"105 3","pages":"Pages 521-524"},"PeriodicalIF":0.0000,"publicationDate":"1993-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0742-8413(93)90095-3","citationCount":"13","resultStr":"{\"title\":\"In vivo evaluation of reuterin and its combinations with suramin, melarsoprol, dl-α-difluoromethylornithine and bleomycin in mice infected with Trypanosoma brucei brucei\",\"authors\":\"Manasses K. Yunmbam, John F. Roberts\",\"doi\":\"10.1016/0742-8413(93)90095-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>1. <em>Trypanosoma brucei brucei</em> -infected mouse models treated with a new antibiotic, reuterin, showed reduction of the levels of parasitemia and prolonged survival of the mice.</p><p>2. Cures of the parasitemia were observed in groups of mice treated with combinations of reuterin and suramin or melarsoprol.</p><p>3. Reuterin administered in combination with bleomycin or <span>dl</span>-α-difluoromethylornithine showed temporary remission of the parasitemia in groups of mice.</p></div>\",\"PeriodicalId\":72650,\"journal\":{\"name\":\"Comparative biochemistry and physiology. C: Comparative pharmacology\",\"volume\":\"105 3\",\"pages\":\"Pages 521-524\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1993-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0742-8413(93)90095-3\",\"citationCount\":\"13\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Comparative biochemistry and physiology. C: Comparative pharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0742841393900953\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comparative biochemistry and physiology. C: Comparative pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0742841393900953","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
In vivo evaluation of reuterin and its combinations with suramin, melarsoprol, dl-α-difluoromethylornithine and bleomycin in mice infected with Trypanosoma brucei brucei
1. Trypanosoma brucei brucei -infected mouse models treated with a new antibiotic, reuterin, showed reduction of the levels of parasitemia and prolonged survival of the mice.
2. Cures of the parasitemia were observed in groups of mice treated with combinations of reuterin and suramin or melarsoprol.
3. Reuterin administered in combination with bleomycin or dl-α-difluoromethylornithine showed temporary remission of the parasitemia in groups of mice.
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