D. Mourelatos , E. Mylonaki , A. Papageorgiou , L. Boutis , A. Paradelis , A. Anastasiou , P. Catsoulacos
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Comparative study of SCE induction and cytostatic effects by homo-azasteroidal esters of N,N-bis(2-chloroethyl)aminobenzoic acid in human lymphocytes
The effect of homo-azasteroidal esters of benzoic acid mustard isomers and the 4-methyl derivatives, which have steroidal lactams as a biological basis, on cytogenetic damage was studied. Twenty compounds were comparatively studied, on a molar basis, as regards their ability to induce sister-chromatid exchanges (SCEs) and cell division delays.
A correlation between potency for SCE induction, effectiveness in cell division delay and previously established antitumor activity of these compounds was observed.
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