严重运动波动的帕金森病患者视觉引导随机扫视和记忆扫视的开始。

C Müller, S Wenger, L Fertl, E Auff
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引用次数: 17

摘要

我们研究了9名患有严重运动波动的帕金森病患者和9名年龄匹配的对照组的扫视启动到视觉引导的随机时间和记忆目标。与“打开”状态下骨骼运动的显著改善相反,在“打开”状态下,与“关闭”状态相比,患者在视觉引导下的随机扫视和记忆扫视的跳眼潜伏期都有所增加。骨骼肌和动眼肌功能分离的结果表明,帕金森病患者眼跳肌启动的普遍概念在严重波动的患者中并不成立,因为多巴胺能刺激似乎增加了这些患者的眼跳肌潜伏期。
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Initiation of visual-guided random saccades and remembered saccades in parkinsonian patients with severe motor-fluctuations.

We studied the initiation of saccades to visual-guided random time and remembered targets in a group of nine Parkinsonian patients with severe motor fluctuations and in 9 age matched control subjects. In contrast to a marked skeletomotor improvement during the "on" condition, saccadic latencies for both visual-guided random saccades and remembered saccades were increased in the patients during the "on" condition compared to the "off" condition. This result of dissociation between skeletomotor and oculomotor function indicates that common concepts of saccadic initiation in parkinsonian patients do not hold true in patients with severe fluctuations since dopaminergic stimulation seems to increase saccadic latencies in these patients.

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