{"title":"黑荆芥天然汁中黄酮类化合物、芦丁和芦丁-镁复合物对组胺和血清素诱导炎症实验模型的抗炎作用。","authors":"P Borissova, S Valcheva, A Belcheva","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The antiinflammatory effects of the anthocyane flavonoids in the natural juice from Aronia melanocarpa and of rutin-magnesium complex, the water-soluble derivative of rutin were studied in comparison with rutin. Two experimental models of inflammation were used. Inflammation of rat hind paw was induced either by 0.5% solution of histamine or by 0.01% solution of serotonin. The swelling of the rat paw was measured oncometrically by a pletismometer. The results showed that the anthocyane flavonoids from the natural juice of Aronia melanocarpa exerted more pronounced effects as compared to rutin in both models of inflammation. The rutin-magnesium complex did not exhibit any antiinflammatory activity against histamine-induced inflammation. Its effects against serotonin-induced inflammation were comparable to those of rutin.</p>","PeriodicalId":7035,"journal":{"name":"Acta physiologica et pharmacologica Bulgarica","volume":"20 1","pages":"25-30"},"PeriodicalIF":0.0000,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antiinflammatory effect of flavonoids in the natural juice from Aronia melanocarpa, rutin and rutin-magnesium complex on an experimental model of inflammation induced by histamine and serotonin.\",\"authors\":\"P Borissova, S Valcheva, A Belcheva\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The antiinflammatory effects of the anthocyane flavonoids in the natural juice from Aronia melanocarpa and of rutin-magnesium complex, the water-soluble derivative of rutin were studied in comparison with rutin. Two experimental models of inflammation were used. Inflammation of rat hind paw was induced either by 0.5% solution of histamine or by 0.01% solution of serotonin. The swelling of the rat paw was measured oncometrically by a pletismometer. The results showed that the anthocyane flavonoids from the natural juice of Aronia melanocarpa exerted more pronounced effects as compared to rutin in both models of inflammation. The rutin-magnesium complex did not exhibit any antiinflammatory activity against histamine-induced inflammation. Its effects against serotonin-induced inflammation were comparable to those of rutin.</p>\",\"PeriodicalId\":7035,\"journal\":{\"name\":\"Acta physiologica et pharmacologica Bulgarica\",\"volume\":\"20 1\",\"pages\":\"25-30\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1994-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta physiologica et pharmacologica Bulgarica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta physiologica et pharmacologica Bulgarica","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Antiinflammatory effect of flavonoids in the natural juice from Aronia melanocarpa, rutin and rutin-magnesium complex on an experimental model of inflammation induced by histamine and serotonin.
The antiinflammatory effects of the anthocyane flavonoids in the natural juice from Aronia melanocarpa and of rutin-magnesium complex, the water-soluble derivative of rutin were studied in comparison with rutin. Two experimental models of inflammation were used. Inflammation of rat hind paw was induced either by 0.5% solution of histamine or by 0.01% solution of serotonin. The swelling of the rat paw was measured oncometrically by a pletismometer. The results showed that the anthocyane flavonoids from the natural juice of Aronia melanocarpa exerted more pronounced effects as compared to rutin in both models of inflammation. The rutin-magnesium complex did not exhibit any antiinflammatory activity against histamine-induced inflammation. Its effects against serotonin-induced inflammation were comparable to those of rutin.
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