由人细小病毒引起的新生儿短暂性红细胞减少症。

O Tugal, B Pallant, N Shebarek, S Jayabose
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引用次数: 0

摘要

目的:我们描述了一个新生儿男婴贫血,在他的血清中检测到人细小病毒(HPV)抗体。患者及方法:重度网状红细胞减少症及贫血持续至出生后第11天。此后观察到网状细胞增多症。经临床及实验室检查,免疫溶血性贫血、胎母出血、胎盘出血、宫内感染均为阴性。婴儿和母亲血清中hpv特异性IgM和IgG均为阳性。结果:尽管有严重的贫血,婴儿在临床上保持稳定。他的血红蛋白水平稳步上升,伴有持续的网状红细胞增多症。他现在14个月大,血红蛋白正常。结论:HPV抗体检测提示其与先天性纯红细胞发育不全的发生有因果关系。在评估新生儿贫血时应考虑HPV感染的可能性。
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Transient erythroblastopenia of the newborn caused by human parvovirus.

Purpose: We describe a newborn baby boy with anemia in whom human parvovirus (HPV) antibodies were detected in his serum.

Patients and methods: Severe reticulocytopenia and anemia lasted until day 11 after his birth. Thereafter reticulocytosis was observed. Work-ups for immune hemolytic anemia, fetomaternal hemorrhage, placental hemorrhage, intrauterine infections were negative by clinical and laboratory analysis. HPV-specific IgM and IgG were positive on both the baby's and the maternal serum.

Results: Despite severe anemia, the baby remained clinically stable. His hemoglobin levels steadily increased along with ongoing reticulocytosis. He is now 14 months old with normal hemoglobin.

Conclusions: Detection of HPV antibodies indicated its causal relation to the development of congenital pure red cell aplasia. The possibility of HPV infection should be considered in the assessment of anemia of the newborn.

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