Okuda Y., Ezure M., Tsukahara K., Sawada T., Mizutani M., Katori T., Bannai C., Yamashita K.
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Eicosapentaenoic Acid Enhances Intracellular Free Calcium in Cultured Human EndothelialCells
Eicosapentaenoic acid (EPA) caused elevations of intracellular free Ca2+ concentration ([Ca2+]i) measured by fura-2 fluorescence in cultured human endothelial cells. The EPA induced increase in [Ca2+]i could still be observed when either cyclooxygenase or lipoxygenase inhibitors were added. These results suggest that EPA itself rather than its metabolites has direct effects on intracellular Ca2+ mobilization, causing the elevation of [Ca2+]i.
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