中毒性油综合征:用中毒性油喂养豚鼠肾功能的研究

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-03-01 DOI:10.1016/0742-8413(93)90019-H

C. Sánchez-Bernal, M. Sánchez-Martín, A.Sánchez Llorente, J.A. Cabezas, N.Pérez González

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引用次数: 1

摘要

1. β- n -乙酰氨基葡萄糖酶(NAG, EC 3.2.1)的比较研究研究了在不同条件下口服“毒油”的豚鼠尿液和肾脏中β-半乳糖苷酶(EC 3.2.1.23)活性、蛋白浓度和肌酐清除率。在不同的给油条件下，尿液中的酶活性没有显著变化。相比之下，在肾脏中，β-d-半乳糖苷酶在所有治疗中都比未治疗的对照组显著增加。治疗4周后，治疗组尿蛋白排泄量、肌酐浓度和肌酐清除率明显高于对照组。用先前加热过的油处理28天的动物的相对肾脏重量(g100 g体重量)显著降低。

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Toxic oil syndrome: a study of renal function in guinea pigs fed toxic oil

1. Comparative studies of β-N-acetylglucosaminidase (NAG, EC 3.2.1. 52) and β-galactosidase (EC 3.2.1.23) activities, protein concentration and creatinine clearance, were carried out in urine and kidney from guinea pigs treated with “toxic oil”, orally administered under different conditions, related to controls.

2. Enzyme activities did not vary significantly in urine with any of the studied conditions of oil administration. By contrast, in kidney, β-d-galactosidase disclosed a significant increase in all the treatments studied when compared to controls without treatment.

3. Urinary protein excretion, creatinine concentration and creatinine clearance were significantly greater in treated animals than in controls after 4 weeks of treatment.

4. Relative kidney weight ( $g 100$ g body wt), was significantly lower in animals treated for 28 days with previously heated oil.

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Comparative biochemistry and physiology. C: Comparative pharmacology

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