解剖显微镜在皮肤癌手术治疗中的应用。

D T Shum, L C Guenther, D Viswanatha
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引用次数: 0

摘要

切除皮肤癌的皮肤病理检查有双重目的,即确定恶性肿瘤的性质和评估切除边缘是否有肿瘤累及的证据。传统的组织学技术,包括莫氏显微摄影手术中规定的水平冷冻切片来评估切除边缘,通常是乏味的,而且不是没有很多陷阱。在本研究中,使用立体解剖显微镜与常规显微镜检查54例临床诊断为癌症的皮肤标本进行比较。我们的研究结果表明,解剖显微镜在诊断基底细胞癌和鳞状细胞癌以及检测肿瘤累及切除边缘方面更有效和准确。在三维空间中可视化边缘表面的能力允许对所涉及的站点进行彻底检查和快速定位和绘图。不存在因固定、冷冻或切片引起的组织伪影。由于成本较低,操作方便,我们认为解剖显微镜是一种更优越的仪器。它在皮肤癌的外科治疗中的有用性应该被强调并进一步验证。
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Usefulness of the dissecting microscope in the surgical management of skin cancers.

Dermatopathological examination of excised skin cancers serves the dual purposes of defining the nature of the malignancies and evaluating the resection margins for evidence of tumor involvement. Conventional histological techniques, including horizontal frozen sections as prescribed in Mohs micrographic surgery to evaluate resection margins, can often be tedious and not without many pitfalls. In this study, the use of a stereoscopic dissecting microscope is compared with routine microscopy in the examination of 54 skin specimens resected with the clinical diagnosis of cancer. Our results show that the dissecting microscope is more efficient and as accurate in diagnosing basal and squamous cell carcinomas, and in detecting tumor involvement of resection margins. The ability to visualize marginal surfaces in three dimensions allows for a thorough examination and quick localization and mapping of the involved sites. Tissue artifacts due to fixation, freezing, or sectioning are nonexistent. With the lower cost and ease of operation, we suggest that the dissecting microscope is a more superior instrument. Its usefulness in the surgical management of skin cancers should be emphasized and further validated.

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A better needle holder. Cutaneous ischemia caused by local anesthesia containing a vasoconstrictor. Spot dermabrasion. Rapid staining with carcinoembryonic antigen aids limited excision of extramammary Paget's disease treated by Mohs surgery. Extramammary Paget's disease. A recalcitrant enigma.
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