Peter ten Dijke , Petra Franzén , Hidetoshi Yamashita , Hidenori Ichijo , Carl-Henrik Heldin , Kohei Miyazono
{"title":"丝氨酸/苏氨酸激酶受体","authors":"Peter ten Dijke , Petra Franzén , Hidetoshi Yamashita , Hidenori Ichijo , Carl-Henrik Heldin , Kohei Miyazono","doi":"10.1016/0955-2235(94)90017-5","DOIUrl":null,"url":null,"abstract":"<div><p>A new family of transmembrane receptors that contain intracellular serine/threonine kinase domains is emerging. Ligands for this class of receptors include members of the transforming growth factor-β (TGF-β) superfamily, e.g. TGF-βs and activins. TGF-βs exert their effects on target cells via formation of heteromeric serine/threonine kinase complexes (TGF-β type I and type II receptors). Other components, i.e. TGF-β type III receptor and endoglin, appear to have more indirect roles, e.g. to present ligands to the signalling receptors. Given the structural similarity between members of the TGF-β superfamily, other ligands in this family may act through structurally and functionally similar serine/threonine kinase receptors.</p></div>","PeriodicalId":77335,"journal":{"name":"Progress in growth factor research","volume":"5 1","pages":"Pages 55-72"},"PeriodicalIF":0.0000,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0955-2235(94)90017-5","citationCount":"87","resultStr":"{\"title\":\"Serine/threonine kinase receptors\",\"authors\":\"Peter ten Dijke , Petra Franzén , Hidetoshi Yamashita , Hidenori Ichijo , Carl-Henrik Heldin , Kohei Miyazono\",\"doi\":\"10.1016/0955-2235(94)90017-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A new family of transmembrane receptors that contain intracellular serine/threonine kinase domains is emerging. Ligands for this class of receptors include members of the transforming growth factor-β (TGF-β) superfamily, e.g. TGF-βs and activins. TGF-βs exert their effects on target cells via formation of heteromeric serine/threonine kinase complexes (TGF-β type I and type II receptors). Other components, i.e. TGF-β type III receptor and endoglin, appear to have more indirect roles, e.g. to present ligands to the signalling receptors. Given the structural similarity between members of the TGF-β superfamily, other ligands in this family may act through structurally and functionally similar serine/threonine kinase receptors.</p></div>\",\"PeriodicalId\":77335,\"journal\":{\"name\":\"Progress in growth factor research\",\"volume\":\"5 1\",\"pages\":\"Pages 55-72\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1994-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0955-2235(94)90017-5\",\"citationCount\":\"87\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress in growth factor research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0955223594900175\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in growth factor research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0955223594900175","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A new family of transmembrane receptors that contain intracellular serine/threonine kinase domains is emerging. Ligands for this class of receptors include members of the transforming growth factor-β (TGF-β) superfamily, e.g. TGF-βs and activins. TGF-βs exert their effects on target cells via formation of heteromeric serine/threonine kinase complexes (TGF-β type I and type II receptors). Other components, i.e. TGF-β type III receptor and endoglin, appear to have more indirect roles, e.g. to present ligands to the signalling receptors. Given the structural similarity between members of the TGF-β superfamily, other ligands in this family may act through structurally and functionally similar serine/threonine kinase receptors.
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