酮洛芬2.5%凝胶与安慰剂凝胶治疗急性软组织损伤的比较。

O Airaksinen, J Venãlãinen, T Pietilãinen
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引用次数: 0

摘要

在单中心进行了一项平行、双盲、安慰剂对照和随机研究,使用酮洛芬2.5%凝胶治疗急性软组织损伤。患者每天使用凝胶两次,持续7天,相当于每天250毫克酮洛芬。分别于第3天和第7天采用VAS、主观评价和痛阈测量法进行评估。研究组29例,对照组27例。酮洛芬组休息时疼痛明显减轻,而安慰剂组差异不显著。在副作用方面,两组之间没有发现差异。两组患者均出现局部皮肤刺激。我们的研究结果表明,酮洛芬2.5%凝胶在治疗软组织损伤方面是安全的,优于安慰剂。
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Ketoprofen 2.5% gel versus placebo gel in the treatment of acute soft tissue injuries.

A parallel, double-blind, placebo controlled and randomized study in a single center was done with ketoprofen 2.5% gel to treat acute soft tissue injuries. Patients applied the gel twice a day for seven days, corresponding to 250 mg of ketoprofen per day. Assessments were made on the third and seventh day by VAS, subjective evaluation and pain threshold algometry. The study group consisted of 29 patients and the control group 27 patients. Pain at rest was significantly relieved in the ketoprofen group, whereas in the placebo group the difference was not significant. In terms of side-effects, no difference between the groups was noticed. In both groups, local dermal irritation was found. Our results suggested that ketoprofen 2.5% gel was safe and superior to placebo in the treatment of soft tissue injuries.

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