{"title":"以合成多离子为基础构建人工免疫原和疫苗的分子基础。","authors":"R M Khaitov","doi":"10.2500/108854195778702648","DOIUrl":null,"url":null,"abstract":"<p><p>The molecular and cellular mechanisms of action of synthetic polyions on immunogenesis are reviewed. The results of studies of principal properties of polyionic immunostimulators and of the cell responses to the action of these stimulants have been used to construct artificial antigen-polyion complexes with enhanced immunogenic properties. The immunizing properties of such macromolecular complexes, constructed with the use of bacterial or viral antigens, are analyzed.</p>","PeriodicalId":7423,"journal":{"name":"Allergy proceedings : the official journal of regional and state allergy societies","volume":"16 5","pages":"255-60"},"PeriodicalIF":0.0000,"publicationDate":"1995-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2500/108854195778702648","citationCount":"2","resultStr":"{\"title\":\"Molecular bases for the construction of artificial immunogens and vaccines based on synthetic polyions.\",\"authors\":\"R M Khaitov\",\"doi\":\"10.2500/108854195778702648\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The molecular and cellular mechanisms of action of synthetic polyions on immunogenesis are reviewed. The results of studies of principal properties of polyionic immunostimulators and of the cell responses to the action of these stimulants have been used to construct artificial antigen-polyion complexes with enhanced immunogenic properties. The immunizing properties of such macromolecular complexes, constructed with the use of bacterial or viral antigens, are analyzed.</p>\",\"PeriodicalId\":7423,\"journal\":{\"name\":\"Allergy proceedings : the official journal of regional and state allergy societies\",\"volume\":\"16 5\",\"pages\":\"255-60\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1995-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.2500/108854195778702648\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Allergy proceedings : the official journal of regional and state allergy societies\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2500/108854195778702648\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Allergy proceedings : the official journal of regional and state allergy societies","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2500/108854195778702648","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Molecular bases for the construction of artificial immunogens and vaccines based on synthetic polyions.
The molecular and cellular mechanisms of action of synthetic polyions on immunogenesis are reviewed. The results of studies of principal properties of polyionic immunostimulators and of the cell responses to the action of these stimulants have been used to construct artificial antigen-polyion complexes with enhanced immunogenic properties. The immunizing properties of such macromolecular complexes, constructed with the use of bacterial or viral antigens, are analyzed.
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