显性癌基因、肿瘤抑制因子和放射敏感性。

Cellular & molecular biology research Pub Date : 1995-01-01

V Chiarugi, L Magnelli, M Cinelli, A Turchetti, M Ruggiero

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摘要

文献中出现了各种相互矛盾的结果，这些结果是关于显性致癌基因对许多人类和动物细胞系的辐照敏感性和抗癌药物的影响。在本报告中，我们提供证据支持以下假设:肿瘤抑制基因p53和细胞凋亡抑制基因bcl2调节显性癌基因的作用，显性癌基因对耐药性或敏感性的影响取决于p53和bcl2表达之间的平衡。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Dominant oncogenes, tumor suppressors, and radiosensitivity.

A variety of conflicting results appeared in the literature concerning the effect of dominant oncogenes on the sensitivity to irradiation and to anticancer agents in a number of cell lines of human and animal origin. In this report we provide evidence supporting the hypothesis that the tumor suppressor gene p53 and the apoptosis suppressor gene bcl2 modulate the effect of dominant oncogenes and that the effect of dominant oncogenes on resistance or sensitivity is dependent on the balance between the expression of p53 and bcl2.

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Cellular & molecular biology research

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