{"title":"酶联免疫吸附试验(ELISA)测定人血浆中活化因子XII(哈格曼因子)。","authors":"R P Ford, M P Esnouf, A I Burgess, A Sarphie","doi":"10.1080/01971529608005783","DOIUrl":null,"url":null,"abstract":"<p><p>A direct enzyme-linked immunosorbent assay (ELISA) employing 2/215 mouse monoclonal hybridoma antibody is described. The assay is capable of detecting activated factor XII in human plasma and can be used to assess early detection of the intrinsic blood coagulation pathway. No cross reactivity with human factor XII zymogen has been found. The assay was used to assess activation of factor XII in patients with renal failure, pregnancy and diabetes compared to a control group.</p>","PeriodicalId":16060,"journal":{"name":"Journal of immunoassay","volume":"17 2","pages":"119-31"},"PeriodicalIF":0.0000,"publicationDate":"1996-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01971529608005783","citationCount":"46","resultStr":"{\"title\":\"An enzyme-linked immunosorbent assay (ELISA) for the measurement of activated factor XII (Hageman factor) in human plasma.\",\"authors\":\"R P Ford, M P Esnouf, A I Burgess, A Sarphie\",\"doi\":\"10.1080/01971529608005783\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A direct enzyme-linked immunosorbent assay (ELISA) employing 2/215 mouse monoclonal hybridoma antibody is described. The assay is capable of detecting activated factor XII in human plasma and can be used to assess early detection of the intrinsic blood coagulation pathway. No cross reactivity with human factor XII zymogen has been found. The assay was used to assess activation of factor XII in patients with renal failure, pregnancy and diabetes compared to a control group.</p>\",\"PeriodicalId\":16060,\"journal\":{\"name\":\"Journal of immunoassay\",\"volume\":\"17 2\",\"pages\":\"119-31\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1996-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1080/01971529608005783\",\"citationCount\":\"46\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of immunoassay\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/01971529608005783\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of immunoassay","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/01971529608005783","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
An enzyme-linked immunosorbent assay (ELISA) for the measurement of activated factor XII (Hageman factor) in human plasma.
A direct enzyme-linked immunosorbent assay (ELISA) employing 2/215 mouse monoclonal hybridoma antibody is described. The assay is capable of detecting activated factor XII in human plasma and can be used to assess early detection of the intrinsic blood coagulation pathway. No cross reactivity with human factor XII zymogen has been found. The assay was used to assess activation of factor XII in patients with renal failure, pregnancy and diabetes compared to a control group.
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