{"title":"分化HL-60细胞中c-myb过表达对5-脂氧合酶基因的抑制作用","authors":"André Ponton , Jean-Paul Thirion , Pierre Siroie","doi":"10.1016/S0090-6980(96)00140-2","DOIUrl":null,"url":null,"abstract":"<div><p>This paper reports on the involvement of c-MYB in the regulation of 5-lipoxygenase gene expression during differentiation of human HL-60 cells. We demonstrate that c-MYB binds, the 5-lipoxygenase promoter in undifferentiated cells but not in DMSQ-diif ferentiated cells. Also, we show that overexpression of <em>c-myb</em> cDNA in differentiated HL-60 cells represses the 5-lipoxygenase gene expression.</p></div>","PeriodicalId":20653,"journal":{"name":"Prostaglandins","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0090-6980(96)00140-2","citationCount":"16","resultStr":"{\"title\":\"Repression of the 5-lipoxygenase gene by c-myb overexpression in differentiated HL-60 cells\",\"authors\":\"André Ponton , Jean-Paul Thirion , Pierre Siroie\",\"doi\":\"10.1016/S0090-6980(96)00140-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>This paper reports on the involvement of c-MYB in the regulation of 5-lipoxygenase gene expression during differentiation of human HL-60 cells. We demonstrate that c-MYB binds, the 5-lipoxygenase promoter in undifferentiated cells but not in DMSQ-diif ferentiated cells. Also, we show that overexpression of <em>c-myb</em> cDNA in differentiated HL-60 cells represses the 5-lipoxygenase gene expression.</p></div>\",\"PeriodicalId\":20653,\"journal\":{\"name\":\"Prostaglandins\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1997-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0090-6980(96)00140-2\",\"citationCount\":\"16\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Prostaglandins\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0090698096001402\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostaglandins","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0090698096001402","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Repression of the 5-lipoxygenase gene by c-myb overexpression in differentiated HL-60 cells
This paper reports on the involvement of c-MYB in the regulation of 5-lipoxygenase gene expression during differentiation of human HL-60 cells. We demonstrate that c-MYB binds, the 5-lipoxygenase promoter in undifferentiated cells but not in DMSQ-diif ferentiated cells. Also, we show that overexpression of c-myb cDNA in differentiated HL-60 cells represses the 5-lipoxygenase gene expression.
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