V Nagarajan, V Pattabhi, A Johnson, V Bobde, S Durani
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引用次数: 0
摘要
确定了具有D手性残基的杂手性肽boc - val1 -D- ala2 - leu3 - ala1 - ome的晶体结构[a = 40.44(1)， b = 4.887(5)， c = 15.381(5) a， β = 109.6(1)度，空间群C2, Z = 4, R = 0.11]。肽呈平行的β片结构，末端有明显的局部弯曲。结构是由N-H…O和C - h…O氢键。连续的C α - h…在这个结构中观察到的O氢键是一个独特的观察。
Crystal structures of heterochiral peptides. Part II. tert-Boc-valyl-D-alanyl-leucyl-alanyl methoxide.
Crystal structure of a heterochiral peptide, viz. Boc-Val1-D-Ala2-Leu3-Ala4-OMe with a D chiral residue in the second position of a sequence, has been determined [a = 40.44(1), b = 4.887(5), c = 15.381(5) A, beta = 109.6(1)degrees, space group C2, Z = 4, R = 0.11]. The peptide is in a parallel beta-sheet structure terminated by a distinct local bend. The structure is established by N-H...O as well as C alpha-H...O hydrogen bonds. The contiguous C alpha-H...O hydrogen bond observed in this structure is an unique observation.
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