肺假丝菌L-733,560和L-743,872对两性霉素B和氟康唑耐药假丝菌的体外生长抑制活性:测定条件的影响

Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology Pub Date : 1997-07-01

P W Nelson, M Lozano-Chiu, J H Rex

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引用次数: 0

摘要

L-733,560和L-743,872是水溶性肺菌素，具有较强的抗真菌活性。从ncls M27-T方法和不同的测试格式(微稀释vs大稀释)、读取时间(24 h vs 48 h)和测试介质(RPMI 1640 vs抗生素培养基3)开始，我们已经证明，这些化合物的MIC可以显著改变:微稀释格式、24小时后读取和抗生素培养基3的使用都降低了测量的MIC。氟康唑和两性霉素B均未出现交叉耐药。

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In vitro growth-inhibitory activity of pneumocandins L-733,560 and L-743,872 against putatively amphotericin B- and fluconazole-resistant Candida isolates: influence of assay conditions.

L-733,560 and L-743,872 are water-soluble pneumocandins with potent antifungal activity. By beginning with the NCCLS M27-T method and varying test format (microdilution vs macrodilution), time of reading (24 h vs 48 h), and test medium (RPMI 1640 vs Antibiotic Medium 3), we have demonstrated that the MICs for these compounds can be altered significantly: the microdilution format, reading after 24 h and use of Antibiotic Medium 3 all reduced the measured MIC. No cross-resistance was demonstrated with either fluconazole or amphotericin B.

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Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology

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