通过增加细胞内谷胱甘肽过氧化物酶和细胞外抗氧化剂增强阿霉素处理的MCR-5肺成纤维细胞的耐药性

Biochemical and molecular medicine Pub Date : 1997-10-01 DOI:10.1006/bmme.1997.2612

Angelo Vanella , Agata Campisi, Claudia di Giacomo, Valeria Sorrenti, Giuseppe Vanella, Rosaria Acquaviva

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引用次数: 10

摘要

大量证据表明活性氧在阿霉素(ADM)引起的心脏毒性和皮肤坏死中起病因学作用。在培养的MCR-5肺成纤维细胞中添加硒可提高其谷胱甘肽过氧化物酶活性;这种增加伴随着细胞对ADM毒性的抗性增强。此外，外源性抗氧化系统的存在，如超氧化物歧化酶、过氧化氢酶、维生素E、二甲亚砜和脱铁胺(一种铁螯合剂)，对adm介导的损伤有显著的保护作用。

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Enhanced Resistance of Adriamycin-Treated MCR-5 Lung Fibroblasts by Increased Intracellular Glutathione Peroxidase and Extracellular Antioxidants

Considerable evidence indicates that reactive oxygen species play an etiological role in both cardiotoxicity and the skin necrosis induced by adriamycin (ADM). An increase in glutathione peroxidase activity on addition of selenium to cultured MCR-5 lung fibroblasts was observed; this increase was accompanied by enhanced cellular resistance to ADM toxicity. Moreover, the presence of exogenous antioxidant systems, such as superoxide dismutase, catalase, vitamin E, dimethylsulfoxide, and desferroxamine, an iron chelating agent, resulted in significant protection from ADM-mediated damage.

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Biochemical and molecular medicine

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